SOCS4 抗体 (AA 227-254)
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北京 101111
Quick Overview for SOCS4 抗体 (AA 227-254) (ABIN3029046)
抗原
See all SOCS4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 227-254
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 227-254 from the human protein was used as the immunogen for this SOCS4 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the SOCS4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the SOCS4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))
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别名
- SOCS4
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背景
- SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. [UniProt]
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UniProt
- Q8WXH5
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途径
- JAK/STAT Signaling, EGFR Signaling Pathway
抗原
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