SIRT5 抗体 (AA 263-292)
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北京 101111
Quick Overview for SIRT5 抗体 (AA 263-292) (ABIN3032595)
抗原
See all SIRT5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 263-292
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纯化方法
- Purified
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免疫原
- A portion of amino acids 263-292 from the human protein was used as the immunogen for this SIRT5 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the SIRT5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:50-1:100,Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the SIRT5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- SIRT5 (Sirtuin 5 (SIRT5))
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别名
- SIRT5
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背景
- SIRT5 is an NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity, however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. [UniProt]
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UniProt
- Q9NXA8
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途径
- SARS-CoV-2 Protein Interactome
抗原
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