RUNX1 抗体 (C-Term)
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Quick Overview for RUNX1 抗体 (C-Term) (ABIN3032498)
抗原
See all RUNX1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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纯化方法
- Antigen affinity purified
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免疫原
- This Runx1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 426-459 amino acids from the C-terminal region of mouse Runx1.
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亚型
- Ig Fraction
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应用备注
- Titration of the Runx1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Runx1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))
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别名
- Runx1
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背景
- CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Essential for the development of normal hematopoiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B- dependent transcriptional activation (By similarity).
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UniProt
- Q03347
抗原
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