REST 抗体 (AA 542-570)
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北京 101111
Quick Overview for REST 抗体 (AA 542-570) (ABIN3028976)
抗原
See all REST 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 542-570
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 542-570 from the human protein was used as the immunogen for this REST antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the REST antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the REST antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- REST (RE1-Silencing Transcription Factor (REST))
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别名
- REST
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背景
- Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
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UniProt
- Q13127
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途径
- Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity
抗原
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