RAN 抗体 (AA 12-39)
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北京 101111
Quick Overview for RAN 抗体 (AA 12-39) (ABIN3032431)
抗原
See all RAN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 12-39
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交叉反应 （详细）
- Expected species reactivity: Rat, Bovine, Primate, Chicken, Zebrafish, Xenopus,Yeast, C. elegans
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纯化方法
- Purified
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免疫原
- A portion of amino acids 12-39 from the human protein was used as the immunogen for this RAN antibody.
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亚型
- Ig Fraction
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anti-RAN, Member RAS Oncogene Family (RAN) (AA 1-216) antibody
RAN 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 8D1A6 unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (N-Term) antibodyVerified RAN 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (AA 2-216) antibodyRAN 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (AA 1-216) antibodyRAN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (AA 1-179) antibodyRAN 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (AA 12-39), (N-Term) antibodyRAN 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20229 unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (AA 112-140) antibodyRAN 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) antibodyRAN 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 24GB940 unconjugated Recombinant Antibody
anti-RAN, Member RAS Oncogene Family (RAN) (AA 197-210) antibodyVerified RAN 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (AA 1-216) antibodyRAN 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Titration of the RAN antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50,Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the RAN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- RAN (RAN, Member RAS Oncogene Family (RAN))
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别名
- RAN
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背景
- RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
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UniProt
- P62826
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途径
- Regulatory RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus
抗原
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