Progesterone Receptor 抗体 (AA 349-377)
Quick Overview for Progesterone Receptor 抗体 (AA 349-377) (ABIN3032306)
抗原
See all Progesterone Receptor (PGR) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 349-377
-
纯化方法
- Antigen affinity purified
-
免疫原
- A portion of amino acids 349-377 from the human protein was used as the immunogen for this Progesterone Receptor antibody.
-
亚型
- Ig Fraction
-
-
anti-Progesterone Receptor (PGR) (AA 1-110) antibody
PGR 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 5D10 unconjugated
anti-Progesterone Receptor (PGR) antibodyPGR 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Progesterone Receptor (PGR) (AA 166-411) antibodyPGR 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 2E4B9 unconjugated
anti-Progesterone Receptor (PGR) antibodyPGR 适用: 人, 大鼠, 小鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Progesterone Receptor (PGR) (AA 1-250) antibodyPGR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Progesterone Receptor (PGR) (AA 501-600) antibodyPGR 适用: 人 WB, ELISA, IHC (p), IF (p), IF (cc), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Progesterone Receptor (PGR) (pSer190) antibodyPGR 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Progesterone Receptor (PGR) (AA 483-571) antibodyPGR 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal PGR-2694 unconjugated
anti-Progesterone Receptor (PGR) (pSer400) antibodyPGR 适用: 人, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Progesterone Receptor (PGR) (pSer294) antibodyPGR 适用: 人, 大鼠, 小鼠, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Titration of the Progesterone Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the Progesterone Receptor antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
-
- Progesterone Receptor (PGR)
-
别名
- Progesterone Receptor
-
背景
- As demonstrated in PR-deficient mice, the physiological effects of progesterone depend completely on the presence of its receptor (hPR), a member of the steroid-receptor superfamily of nuclear receptors. The single-copy hPR gene uses separate promoters and translational start sites to produce two isoforms, hPR-A and -B, which are identical except for an additional 165 amino acids present only in the N terminus of -B. Although hPR-B shares many important structural domains as -A, they are in fact two functionally distinct transcription factors, mediating their own response genes and physiological effects with little overlap. Selective ablation of PR-A in a mouse model, resulting in exclusive production of -B, unexpectedly revealed that -B contributes to, rather than inhibits, epithelial cell proliferation both in response to estrogen alone and in the presence of progesterone and estrogen. These results suggest that in the uterus, the PR-A isoform is necessary to oppose estrogen-induced proliferation as well as -B-dependent proliferation. [Wiki]
-
UniProt
- P06401
-
途径
- Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration
抗原
-
