TERT 抗体 (pSer1125)
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北京 101111
Quick Overview for TERT 抗体 (pSer1125) (ABIN3029106)
抗原
See all TERT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer1125
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纯化方法
- Antigen affinity purified
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免疫原
- This phospho-TERT antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS1125 of human TERT.
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亚型
- Ig Fraction
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应用备注
- Titration of the phospho-TERT antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the phospho-TERT antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- TERT (Telomerase Reverse Transcriptase (TERT))
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别名
- TERT
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背景
- Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.
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UniProt
- O14746
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途径
- Telomere Maintenance
抗原
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