PDX1 抗体 (AA 136-169)
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Quick Overview for PDX1 抗体 (AA 136-169) (ABIN3032147)
抗原
See all PDX1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 136-169
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纯化方法
- Antigen affinity purified
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免疫原
- This mouse Pdx1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 136-169 amino acids from the Central region of mouse Pdx1.
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亚型
- Ig Fraction
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应用备注
- Titration of the Pdx1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Pdx1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))
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别名
- Pdx1
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背景
- Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer, the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'.
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UniProt
- P52946
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途径
- Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location
抗原
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