MYB 抗体 (AA 506-534)
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北京 101111
Quick Overview for MYB 抗体 (AA 506-534) (ABIN3029530)
抗原
See all MYB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 506-534
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 506-534 from the human protein was used as the immunogen for this Myb antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the Myb antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:50-1:100,Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Myb antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))
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别名
- Myb
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背景
- Myb is a transcriptional activator, DNA-binding protein that recognizes the sequence 5'-YAAC[GT]G-3'. It participates in the control of proliferation and differentiation of hematopoietic progenitor cells. Myb is a transcription factor related to Myc, and is expressed predominantly in haematopoietic cells and immature gastroepithelial cells. TRAF7 stimulates the sumoylation of Myb at Lys-523 and Lys-499, which are the same sites as those used for PIASy-induced sumoylation. A correlation has been established between reduction in sumoylation of Myb and increase in transcriptional activation. Negative influence on transactivation properties by the negative regulatory domain region of c-Myb depends on upon sumoylation.
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UniProt
- P10242
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途径
- Chromatin Binding, Positive Regulation of Immune Effector Process
抗原
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