MUC4 抗体 (N-Term)
Quick Overview for MUC4 抗体 (N-Term) (ABIN3031870)
抗原
See all MUC4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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纯化方法
- Antigen affinity purified
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免疫原
- This MUC4 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 529-560 amino acids from the N-terminal region of human Mucin-4 alpha chain.
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亚型
- Ig Fraction
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anti-Mucin 4, Cell Surface Associated (MUC4) (AA 79-188) antibody
MUC4 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5B12 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1730-1864) antibodyMUC4 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal MUC4-3105 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1730-1864) antibodyMUC4 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal MUC4-3084 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1501-1613) antibodyMUC4 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 529-560), (N-Term) antibodyMUC4 适用: 人 WB 宿主: 兔 Polyclonal RB49957 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 79-188) antibodyMUC4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1154-1309) antibodyMUC4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1249-1444) antibodyMUC4 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Titration of the MUC4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the MUC4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- MUC4 (Mucin 4, Cell Surface Associated (MUC4))
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别名
- Mucin-4 alpha chain / MUC4
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背景
- May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.
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UniProt
- Q99102
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途径
- Regulation of Leukocyte Mediated Immunity
抗原
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