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LSD1 抗体 (AA 108-142)

This anti-LSD1 antibody is a 兔 多克隆 antibody detecting LSD1 in WB, ELISA, IHC 和 IF. Suitable for 人 和 小鼠.
产品编号 ABIN3031651
发货至: 中国

Quick Overview for LSD1 抗体 (AA 108-142) (ABIN3031651)

抗原

See all LSD1 (KDM1A) 抗体
LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

适用

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人, 小鼠

宿主

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克隆类型

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多克隆

标记

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This LSD1 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
  • 抗原表位

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    AA 108-142

    纯化方法

    Purified

    免疫原

    A portion of amino acids 108-142 from the human protein was used as the immunogen for this LSD1 antibody.

    亚型

    Ig Fraction
  • 应用备注

    Titration of the LSD1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Immunofluorescence: 1:10-1:50

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    In 1X PBS, pH 7.4, with 0.09 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the LSD1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

    别名

    LSD1

    背景

    LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.

    UniProt

    O60341

    途径

    Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, Warburg Effect
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