HAS1 抗体 (AA 166-193)
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北京 101111
Quick Overview for HAS1 抗体 (AA 166-193) (ABIN3031258)
抗原
See all HAS1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 166-193
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交叉反应 （详细）
- Expected species reactivity: Mouse
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 166-193 from the human protein was used as the immunogen for this HAS1 antibody.
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亚型
- Ig Fraction
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anti-Hyaluronan Synthase 1 (HAS1) antibody
HAS1 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 5B5B4 unconjugated
anti-Hyaluronan Synthase 1 (HAS1) antibodyHAS1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronan Synthase 1 (HAS1) antibodyHAS1 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 3E10 unconjugated
anti-Hyaluronan Synthase 1 (HAS1) (AA 74-399) antibodyHAS1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2G5H6 unconjugated
anti-Hyaluronan Synthase 1 (HAS1) (AA 501-578) antibodyHAS1 适用: 人, 小鼠, 大鼠 ELISA, FACS, IF (cc), IF (p), ICC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronan Synthase 1 (HAS1) antibodyHAS1 适用: 人 WB, ELISA, IHC, IF 宿主: 小鼠 Monoclonal 3E10 unconjugated
anti-Hyaluronan Synthase 1 (HAS1) (AA 80-390) antibodyHAS1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronan Synthase 1 (HAS1) (AA 151-271) antibodyHAS1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronan Synthase 1 (HAS1) (AA 166-193) antibodyHAS1 适用: 人 WB 宿主: 兔 Polyclonal RB24040 unconjugated
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应用备注
- Titration of the HAS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the HAS1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- HAS1 (Hyaluronan Synthase 1 (HAS1))
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别名
- HAS1
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背景
- Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.
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UniProt
- Q92839
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途径
- Glycosaminoglycan Metabolic Process
抗原
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