Endothelin 3 抗体 (AA 168-197)
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Quick Overview for Endothelin 3 抗体 (AA 168-197) (ABIN3030805)
抗原
See all Endothelin 3 (EDN3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 168-197
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 168-197 from the human protein was used as the immunogen for this EDN3 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the EDN3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the EDN3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Endothelin 3 (EDN3)
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别名
- EDN3
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背景
- The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
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UniProt
- P14138
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途径
- Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones
抗原
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