Doublecortin 抗体 (AA 107-137)
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Quick Overview for Doublecortin 抗体 (AA 107-137) (ABIN3030770)
抗原
See all Doublecortin (DCX) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 107-137
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交叉反应 (详细)
- Expected species reactivity: Mouse, Rat
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 107-137 from the human protein was used as the immunogen for this DCX antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the DCX antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the DCX antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Doublecortin (DCX)
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别名
- DCX
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背景
- In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.
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UniProt
- O43602
抗原
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