BACE2C 抗体 (AA 310-339)
BACE2 C
适用: 人
WB, IHC, ELISA
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all BACE2C (BACE2 C) products
- BACE2C (BACE2 C) (beta-Site APP-Cleaving Enzyme 2 C (BACE2 C))
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抗原表位
- AA 310-339
- 适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This BACE2C antibody is un-conjugated
- 应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 纯化方法
- Purified
- 免疫原
- A portion of amino acids 310-339 from the human protein was used as the immunogen for this BACE2C antibody.
- 亚型
- Ig Fraction
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anti-beta-Site APP-Cleaving Enzyme 2 C (BACE2 C) (AA 310-339), (C-Term) antibody
BACE2 C 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB2126 unconjugated
anti-beta-Site APP-Cleaving Enzyme 2 C (BACE2 C) antibodyBACE2 C 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Titration of the BACE2C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Aliquot the BACE2C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- 抗原
- BACE2C (BACE2 C) (beta-Site APP-Cleaving Enzyme 2 C (BACE2 C))
- 别名
- BACE2C (BACE2 C 产品)
- 背景
- Amyloid-beta peptide aggregation is a signature of Alzheimer disease and a frequent complication of adult Down syndrome patients. Amyloid-beta is generated by proteolytic processing of the amyloid precursor protein (APP) by beta- and gamma-secretase at the N and C termini, respectively. Presenilin-1 is involved in the gamma-secretase activity. BACE is a transmembrane aspartyl protease with beta-secretase activity. BACE2, also termed ALP56 has 2 pepsin-like active centers, a signal sequence, a propeptide, and a long C-terminal extension including a transmembrane domain, with expression in a wide array of tissues. Northern blot analysis revealed low expression of 2.0- and 2.6-kb BACE2 transcripts in most fetal and adult tissues, with higher expression in adult colon, kidney, pancreas, placenta, prostate, stomach, and trachea. Low levels were also detected in brain, with somewhat higher expression in medulla and spinal cord. In situ hybridization analysis of rat brain found low-level BACE2 expression in contrast to BACE expression. The BACE2 expression pattern does not appear to be consistent with that of a beta-secretase. BACE2 has been mapped to 21q22.3, within the Down syndrome critical region.
- UniProt
- Q9Y5Z0
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