CD13 抗体 (AA 156-184)
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Quick Overview for CD13 抗体 (AA 156-184) (ABIN3029889)
抗原
See all CD13 (ANPEP) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 156-184
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纯化方法
- Purified
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免疫原
- A portion of amino acids 156-184 from the human protein was used as the immunogen for this ANPEP antibody.
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亚型
- IgG2a
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应用备注
- Titration of the ANPEP antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:100-1:250
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the ANPEP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))
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别名
- ANPEP
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背景
- Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.
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UniProt
- P15144
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途径
- Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones
抗原
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