The stated application concentrations are suggested starting points. Titration of the SIRT6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:500,ICC/IF: 1:100,Immunoprecipitation: suitable
限制
仅限研究用
缓冲液
Antibody in PBS with 50 % Glycerol and 0.03 % ProClin 300
储存条件
-20 °C
储存方法
Store the SIRT6 antibody at -20°C.
抗原
SIRT6
(Sirtuin 6 (SIRT6))
别名
SIRT6
背景
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. [UniProt]