GP2 抗体 (AA 35-179)
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Quick Overview for GP2 抗体 (AA 35-179) (ABIN4949728)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 35-179
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无交叉反应
- 小鼠
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纯化方法
- Protein G affinity chromatography
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免疫原
- A partial human recombinant protein corresponding to amino acids 35-179 was used as the immunogen for the GP2 antibody.
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亚型
- IgG2b lambda
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应用备注
- Optimal dilution of the GP2 antibody should be determined by the researcher.\. FACS: 0.5-1 μg/10e6 cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL for 30 min at RT
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the GP2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))
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别名
- Glycoprotein 2 / GP2 / ZAP75
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背景
- GP2 (Glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.
抗原
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