Filaggrin 抗体 (AA 998-1104)
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Quick Overview for Filaggrin 抗体 (AA 998-1104) (ABIN4949677)
抗原
See all Filaggrin (FLG) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 998-1104
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纯化方法
- Protein G affinity chromatography
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免疫原
- Amino acids 998-1104 of human FLG were used as the immunogen for this Filaggrin antibody.
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亚型
- IgG1 kappa
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应用备注
- Optimal dilution of the Filaggrin antibody should be determined by the researcher.\. FACS: 0.5-1 μg/10^6 cells in 0.1ml,IF: 1-2 μg/mL,IHC (FFPE): 0.5-1 μg/mL for 30 min at RT
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the Filaggrin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- Filaggrin (FLG)
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别名
- Filaggrin
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背景
- Filaggrin (FLG) is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
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途径
- Sensory Perception of Sound, Stem Cell Maintenance
抗原
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