HSPB8 抗体
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北京 101111
Quick Overview for HSPB8 抗体 (ABIN492450)
抗原
See all HSPB8 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Detects endogenous and exogenous hsp22 in monomeric, dimeric and tetrameric (weak) forms in Western Blot. Does not cross react with alpha Crystalline. Exogenous HSP22 detected in dimeric form.
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产品特性
- Synonyms: Alpha crystallin C chain, CMT2L, CRYAC, DHMN2, H11, Heat shock 22kDa protein 8, HMN2,HSB8, HspB8
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纯化方法
- Protein G Chromatography.
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免疫原
- His-tagged Human recombinant HSP22
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亚型
- IgG1
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anti-Heat Shock 22kDa Protein 8 (HSPB8) antibody
HSPB8 适用: 人 WB, IHC, IF, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 22kDa Protein 8 (HSPB8) (AA 1-196) antibodyHSPB8 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 22kDa Protein 8 (HSPB8) antibody (Biotin)HSPB8 适用: 人 WB, IHC, IF, ICC, IP 宿主: 兔 Polyclonal Biotin
anti-Heat Shock 22kDa Protein 8 (HSPB8) antibody (APC)HSPB8 适用: 人 WB, IHC, IF, ICC, IP 宿主: 兔 Polyclonal APC
anti-Heat Shock 22kDa Protein 8 (HSPB8) antibody (Atto 390)HSPB8 适用: 人 WB, IHC, IF, ICC, IP 宿主: 兔 Polyclonal Atto 390
anti-Heat Shock 22kDa Protein 8 (HSPB8) antibody (Atto 488)HSPB8 适用: 人 WB, IHC, IF, ICC, IP 宿主: 兔 Polyclonal Atto 488
anti-Heat Shock 22kDa Protein 8 (HSPB8) antibody (Atto 594)HSPB8 适用: 人 WB, IHC, IF, ICC, IP 宿主: 兔 Polyclonal Atto 594
anti-Heat Shock 22kDa Protein 8 (HSPB8) antibody (HRP)HSPB8 适用: 人 WB, IHC, IF, ICC, IP 宿主: 兔 Polyclonal HRP
anti-Heat Shock 22kDa Protein 8 (HSPB8) antibody (PerCP)HSPB8 适用: 人 WB, IHC, IF, ICC, IP 宿主: 兔 Polyclonal PerCP
anti-Heat Shock 22kDa Protein 8 (HSPB8) antibody (PE)HSPB8 适用: 人 WB, IHC, IF, ICC, IP 宿主: 兔 Polyclonal PE
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应用备注
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ELISA. Western blot (1/2000).1 μg/mL was sufficient for detection of Hsp22 in 20 μg of whole rat tissue extract by ECLimmunoblot analysis using Goat anti-mouse IgG: HRP as the secondary antibody. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH 7.4 containing 50 % Glycerol as stabilizer and 0.09 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- HSPB8 (Heat Shock 22kDa Protein 8 (HSPB8))
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别名
- HSP22
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背景
- Hsp22 (HSPB8) is a 196-amino acid protein that is a member of the small heat shock protein super-family and the human protein is most closely related to Hsp27. Similar to most other sHSPs, Hsp22 is predominately transcribed in skeletal muscle and heart, as well as the placenta (1). Hsp22 is a monomeric protein which interacts with HSPB1. It displays temperature-dependent chaperone activity. In a two hybrid screen, HspB8 interacted preferentially with a triple aspartate form of Hsp27 which mimics Hsp27 phosphorylated at Ser15, Ser78, and Ser82, as compared to wild-type Hsp27 (2). HSPB8 has two binding domains (N and C Terminal) that are specific for different binding partners, and has the ability to bind itself and other sHSPs (3). The chaperone-like activity is of great importance to the function of Hsp22 in various processes including proliferation, apoptosis and macroautophagy (4). Mutations in the HSPB8 gene are associated with the inherited peripheral neurpathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L) (5).Synonyms: Alpha crystallin C chain, CMT2L, CRYAC, DHMN2, H11, HMN2, HSB8, Heat shock 22 kDa protein 8, HspB8
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基因ID
- 2030
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UniProt
- Q9UJY2
抗原
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