Lactate Dehydrogenase A 抗体 (N-Term)
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Quick Overview for Lactate Dehydrogenase A 抗体 (N-Term) (ABIN492378)
抗原
See all Lactate Dehydrogenase A (LDHA) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-332, N-Term
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特异性
- The antibody recognizes Human LDHA. Other species not tested.
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产品特性
- Synonyms: LDH-A, L-lactate dehydrogenase A chain, LDH-M, PIG19, NY-REN-59, LDH muscle subunit,Cell proliferation-inducing gene 19 protein, Renal carcinoma antigen NY-REN-59
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纯化方法
- Affinity chromatography on Protein G
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免疫原
- Recombinant human LDHA (1-332aa) purified from E. coli
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亚型
- IgG2b
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应用备注
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ELISA. Western blot (1: 500 - 1: 8000). Immunofluorescence (1: 500 - 1: 8000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH 7.4, 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- Lactate Dehydrogenase A (LDHA)
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别名
- LDHA
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背景
- Lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc and hypoxia-inducible factor (HIF-1). LDHA expression is repressed by SugR in the absence of sugar. Reduction of LDHA causes bioenergetic and oxidative stress leading to cell death. LDHA (LDH-5, M-LDH, or A4), which is the predominant form in skeletal muscle, kinetically favors the conversion of pyruvate to lactate. Therefore, LDH-A is an attractive target for cancer therapy since its expression is largely relegated to skeletal muscle.Synonyms: Cell proliferation-inducing gene 19 protein, L-lactate dehydrogenase A chain, LDH muscle subunit, LDH-A, LDH-M, NY-REN-59, PIG19, Renal carcinoma antigen NY-REN-59
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基因ID
- 3939
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UniProt
- P00338
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途径
- Warburg Effect
抗原
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