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VAMP8 抗体

This anti-VAMP8 antibody is a 小鼠 单克隆 antibody detecting VAMP8 in WB 和 IHC (p). Suitable for 人.
产品编号 ABIN4915080
发货至: 中国

Quick Overview for VAMP8 抗体 (ABIN4915080)

抗原

See all VAMP8 抗体
VAMP8 (Vesicle-Associated Membrane Protein 8 (Endobrevin) (VAMP8))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This VAMP8 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

14C3
  • 交叉反应

    纯化方法

    Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

    免疫原

    This VAMP8 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 2~24 amino acids from the N-terminal region of human VAMP8.

    亚型

    IgG1
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.5 μg/μL

    缓冲液

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    有效期

    12 months
  • 抗原

    VAMP8 (Vesicle-Associated Membrane Protein 8 (Endobrevin) (VAMP8))

    别名

    VAMP8

    背景

    Synonyms: EDB, VAMP-8, Vesicle-associated membrane protein 8, Endobrevin, VAMP8

    Background: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity).

    基因ID

    8673

    UniProt

    Q9BV40
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