SUMO2 抗体
Quick Overview for SUMO2 抗体 (ABIN4914410)
抗原
See all SUMO2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 大鼠
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纯化方法
- Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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免疫原
- Purified His-tagged SUMO2 protein was used to produced this monoclonal antibody.
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亚型
- IgG2b
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应用备注
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WB 1:300-5000
IF(ICC) 1:50-200
IF() -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))
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别名
- SUMO2
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背景
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Synonyms: HSMT3, SMT3B, SUMO3, Smt3A, SMT3H2, Small ubiquitin-related modifier 2, SUMO-2, SMT3 homolog 2, SUMO-3, Sentrin-2, Ubiquitin-like protein SMT3B, SUMO2
Background: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
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基因ID
- 6613
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UniProt
- P61956
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途径
- Methionine Biosynthetic Process
抗原
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