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SUMO2 抗体

The 小鼠 单克隆 anti-SUMO2 antibody is suitable to detect SUMO2 in samples from 人 和 大鼠. It has been validated for WB, IF 和 IF (cc).
产品编号 ABIN4914410
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for SUMO2 抗体 (ABIN4914410)

抗原

See all SUMO2 抗体
SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

适用

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人, 大鼠

宿主

  • 81
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  • 1
小鼠

克隆类型

  • 83
  • 25
单克隆

标记

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This SUMO2 antibody is un-conjugated

应用范围

  • 70
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Western Blotting (WB), Immunofluorescence (IF), Immunofluorescence (Cultured Cells) (IF (cc))

克隆位点

7A3
  • 交叉反应

    人, 大鼠

    纯化方法

    Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

    免疫原

    Purified His-tagged SUMO2 protein was used to produced this monoclonal antibody.

    亚型

    IgG2b
  • 应用备注

    WB 1:300-5000
    IF(ICC) 1:50-200
    IF()

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.5 μg/μL

    缓冲液

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

    别名

    SUMO2

    背景

    Synonyms: HSMT3, SMT3B, SUMO3, Smt3A, SMT3H2, Small ubiquitin-related modifier 2, SUMO-2, SMT3 homolog 2, SUMO-3, Sentrin-2, Ubiquitin-like protein SMT3B, SUMO2

    Background: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

    基因ID

    6613

    UniProt

    P61956

    途径

    Methionine Biosynthetic Process
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