C6orf150 抗体 (AA 1-185)
Quick Overview for C6orf150 抗体 (AA 1-185) (ABIN4911805)
抗原
See all C6orf150 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-185
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交叉反应
- 人
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纯化方法
- Purified by Protein G.
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免疫原
- This MB21D1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-185 amino acids from human MB21D1.
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亚型
- IgG1
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anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 211-395) antibody
C6orf150 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 350-522) antibodyC6orf150 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (pSer420) antibodyC6orf150 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 225-407) antibodyC6orf150 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (Middle Region) antibodyC6orf150 适用: 人, 兔, Cow, 豚鼠, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 273-303), (Middle Region) antibodyC6orf150 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:300-5000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))
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别名
- MB21D1
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背景
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Synonyms: cGAS, h-cGAS, C6orf150, Cyclic GMP-AMP synthase, cGAMP synthase, 2'3'-cGAMP synthase, Mab-21 domain-containing protein 1, MB21D1
Background: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115).
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基因ID
- 115004
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UniProt
- Q8N884
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途径
- Activation of Innate immune Response
抗原
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