Fusobacterium Nucleatum 抗体
This 兔 多克隆 antibody specifically detects Fusobacterium Nucleatum in CLSM, ELISA 和 FACS. It exhibits reactivity toward Fusobacterium nucleatum. It has been mentioned in 3+ publications
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(3 references)
产品编号 ABIN4888518
发货至:
中国
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Quick Overview for Fusobacterium Nucleatum 抗体 (ABIN4888518)
抗原
Fusobacterium Nucleatum
适用
Fusobacterium nucleatum
宿主
兔
克隆类型
多克隆
应用范围
Confocal Laser Scanning Microscopy (CLSM), ELISA, Flow Cytometry (FACS)
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特异性
- Fusobacterium nucleatum, The antibody anti F. nucleatum showed crossreactivity toward S. oralis ATCC9811 at 1:50v/v dilution but not crossreact with S. mutans ATCC 25175 and P. gingivalis ATCC 33277
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产品特性
- Fusobacterium nucleatum is a Gram-negative bacterium that is commonly found in the dental plaque of humans and is frequently associated with gum disease. This bacteria has been shown to play a central role in dental plaque formation and other diseases like gingivitis. This is due to its ability to adhere to a wide range of both Gram-positive and Gram-negative plaque microorganisms. F. nucleatum is very much associated with periodontitis, along with invasive human infections of the head and neck, chest, lung, liver and abdomen. Due to its adherence ability, it can be associated with viruses, which adhere to host tissue cells as an invasion and modulate the host's immune response. The pathogenic potential of Fusobacterium nucleatum and its significance in the development of periodontal diseases, as well as in infections in other organs, have gained new interest for several reasons. First, this bacterium has a very high chance to be pathogenic because of its high frequency in periodontal lesions, its production of irritants that affect the tissue, its ability to co-aggregate and form mutual synergisms with other bacteria in mixed infections, and its ability to form numerous aggregates with other suspected pathogens in periodontal disease. Second, F. nucleatum is very common in clinical infections of other body sites. In the last few years it is intensively investigate the role of Fusobacterium nucleatum in atherosclerosis development and in promoting or inflicting different cancers.
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纯化方法
- Polyclonal immunoglobulins purified by protein A affinity chromatography
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免疫原
- F. nucleatum ATCC 25586 10^10 cells inactivated in glutaraldehyde 2.5%v/v
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied in 100 mM sodium citrate, 50 mM Tris and 0.05 % v/v glycerol. Neutral pH.
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储存条件
- 4 °C
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: "Impact of Fusobacterium nucleatum on immune cell interactions and gene expression in colorectal cancer: a retrospective cohort study." in: Frontiers in immunology, Vol. 16, pp. 1629014, (2025) (PubMed).
: "Colorectal cancer-associated anaerobic bacteria proliferate in tumor spheroids and alter the microenvironment." in: Scientific reports, Vol. 10, Issue 1, pp. 5321, (2021) (PubMed).
: "A dual-species microbial model for studying the dynamics between oral streptococci and periodontal pathogens during biofilm development on titanium surfaces by flow cytometry." in: Research in microbiology, Vol. 167, Issue 5, pp. 393-402, (2017) (PubMed).
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: "Impact of Fusobacterium nucleatum on immune cell interactions and gene expression in colorectal cancer: a retrospective cohort study." in: Frontiers in immunology, Vol. 16, pp. 1629014, (2025) (PubMed).
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- Fusobacterium Nucleatum
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物质类
- Bacteria
抗原
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