PVRL4 抗体 (N-Term)
Quick Overview for PVRL4 抗体 (N-Term) (ABIN4886678)
抗原
See all PVRL4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 53-94, N-Term
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原理
- Anti-PVRL4/NECTIN4 Antibody Picoband®
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序列
- FYRGDSGEQV GQVAWARVDA GEGAQELALL HSKYGL
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-PVRL4/NECTIN4 Antibody Picoband® (ABIN4886678). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human Nectin-4/PVRL4, different from the related mouse sequence by seven amino acids.
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亚型
- IgG
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anti-Poliovirus Receptor-Related 4 (PVRL4) antibody
PVRL4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 91-199) antibodyPVRL4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 151-250) antibodyPVRL4 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (Internal Region) antibodyPVRL4 适用: 人, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 84-96), (Extracellular) antibodyPVRL4 适用: 小鼠 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 1-510) antibodyPVRL4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 31-139) antibodyPVRL4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D7 unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) antibodyPVRL4 适用: 人 FACS 宿主: 兔 Chimeric unconjugated Fc fragment
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 371-510) antibodyPVRL4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 31-317) antibodyPVRL4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
1. Brancati, F., Fortugno, P., Bottillo, I., Lopez, M., Josselin, E., Boudghene-Stambouli, O., Agolini, E., Bernardini, L., Bellacchio, E., Iannicelli, M., Rossi, A., Dib-Lachachi, A., Stuppia, L., Palka, G., Mundlos, S., Stricker, S., Kornak, U., Zambruno, G., Dallapiccola, B.Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome.Am. J. Hum. Genet. 87: 265-273, 2010. 2. Fabre-Lafay, S., Garrido-Urbani, S., Reymond, N., Goncalves, A., Dubreuil, P., Lopez, M. Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17. J. Biol. Chem. 280: 19543-19550, 2005. 3. Muhlebach, M. D., Mateo, M., Sinn, P. L., Prufer, S., Uhlig, K. M., Leonard, V. H. J., Navaratnarajah, C. K., Frenzke, M., Wong, X. X., Sawatsky, B., Ramachandran, S., McCray, P. B., Jr., Cichutek, K., von Messling, V., Lopez, M., Cattaneo, R. Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature 480: 530-533, 2011. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))
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别名
- NECTIN4
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背景
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Synonyms: Nectin-4,Ig superfamily receptor LNIR,Nectin cell adhesion molecule 4 ,Poliovirus receptor-related protein 4,Processed poliovirus receptor-related protein 4,NECTIN4 ,LNIR, PRR4, PVRL4,
Tissue Specificity: Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma. .
Background: PVRL4, also known as Nectin-4, is expressed in human skin, hair follicles, and cultured keratinocytes, but not in fibroblasts. This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
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分子量
- 66 kDa
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基因ID
- 81607
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途径
- Cell-Cell Junction Organization
抗原
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