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Doublecortin 抗体 (N-Term)

Name: Doublecortin 抗体 (N-Term)
SKU: ABIN4886559
Availability: OutOfStock

DCX 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated

Western blot analysis of Doublecortin expression in rat brain extract ( Lane 1) and mouse brain extract ( Lane 2). (Doublecortin 抗体 (N-Term))

1 image

(1 reference)

产品编号 ABIN4886559

发货至: 中国

Datasheet as PDF

抗原 See all Doublecortin (DCX) 抗体

Doublecortin (DCX)
抗原表位
7

7

7

7

5

4

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 74-100, N-Term
适用
111

71

66

4

3

3

2

2

2

1

1

1

1

1
小鼠, 大鼠
宿主
101

11

2

2
兔
Compatible Secondaries
克隆类型
96

20
多克隆
标记
63

9

5

5

5

5

5

4

4

4

1

1

1

1

1

1

1
This Doublecortin antibody is un-conjugated
应用范围
73

41

33

12

12

11

9

8

8

4

3

1

1

1

1
Western Blotting (WB)

原理

Rabbit IgG polyclonal antibody for Neuronal migration protein doublecortin(DCX) detection. Tested with WB in Human,Mouse,Rat.

序列

QSLRFHQNME LDFGHFDERD KTSRNMR

交叉反应（详细）

Predicted Cross Reactivity: human
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

产品特性

Rabbit IgG polyclonal antibody for Neuronal migration protein doublecortin(DCX) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: doublecortin
Protein Name: Neuronal migration protein doublecortin

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of human Doublecortin (74-100aa QSLRFHQNMELDFGHFDERDKTSRNMR).

亚型

IgG

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DCX 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, Rat, Predicted Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Zhang, Du, Yang, Wang, Yu, Huang, Hu, Liu, Fu: "Granulocyte colony-stimulating factor increases the therapeutic efficacy of bone marrow mononuclear cell transplantation in cerebral ischemia in mice." in: BMC neuroscience, Vol. 12, pp. 61, (2011) (PubMed).
抗原

Doublecortin (DCX)

别名

DCX (DCX 产品)

别名

DCX antibody, DBCN antibody, DC antibody, LISX antibody, SCLH antibody, XLIS antibody, Dbct antibody, 18C15.5 antibody, doublecortin antibody, DCX antibody, Dcx antibody

背景

Neuronal migration protein doublecortin, also known as doublin or lissencephalin-X, is a protein that in humans is encoded by the DCX gene. This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms: DBCN | Dbct | DC | DCX | Doublecortex | Doublin | Lis X | Lis-X | Lissencephalin X | Lissencephalin-X | LISX | SCLH | XLIS | O43602

基因ID

1641

UniProt

O43602