Caldesmon 抗体 (AA 1-120)
Quick Overview for Caldesmon 抗体 (AA 1-120) (ABIN4886498)
抗原
See all Caldesmon (CALD1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-120
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原理
- Anti-Caldesmon/CALD1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Caldesmon/CALD1 Antibody Picoband® (ABIN4886498). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E. coli-derived human Caldesmon recombinant protein (Position: M1-E120). Human Caldesmon shares 87.6% amino acid (aa) sequence identity with rat Caldesmon.
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亚型
- IgG
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anti-Caldesmon 1 (CALD1) (AA 26-207) antibody
CALD1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 6F8D2 unconjugated
anti-Caldesmon 1 (CALD1) (AA 434-531) antibodyCALD1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caldesmon 1 (CALD1) (pSer789) antibodyCALD1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caldesmon 1 (CALD1) antibodyCALD1 适用: 人, 大鼠 IHC, StM 宿主: 兔 Monoclonal CALD1-1424R unconjugated Recombinant Antibody
anti-Caldesmon 1 (CALD1) (C-Term) antibodyCALD1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caldesmon 1 (CALD1) (AA 1-240) antibodyCALD1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Caldesmon 1 (CALD1) antibodyCALD1 适用: 人, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Caldesmon 1 (CALD1) antibodyCALD1 适用: 人, 大鼠 IHC, StM 宿主: 兔 Polyclonal unconjugated
anti-Caldesmon 1 (CALD1) antibodyCALD1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal CALD1-820 unconjugated
anti-Caldesmon 1 (CALD1) (AA 1-538) antibodyCALD1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry(Fixed), 1-3 μg/1x106 cells, Human
1. "Entrez Gene: CALD1 caldesmon 1". 2. Humphrey MB, Herrera-Sosa H, Gonzalez G, et al. (1992). "Cloning of cDNAs encoding human caldesmons". Gene 112(2): 197-204. 3. Novy RE, Lin JL, Lin JJ (Oct 1991). "Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells". J Biol Chem 266 (25): 16917-24. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Caldesmon (CALD1) (Caldesmon 1 (CALD1))
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别名
- CALD1
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背景
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Synonyms: Caldesmon,CDM,CALD1,CAD, CDM,
Tissue Specificity: High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular- weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
Background: Caldesmon is a protein that in humans is encoded by the CALD1 gene. It is mapped to 7q33. This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca (2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca (2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
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分子量
- 80 kDa
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基因ID
- 800
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UniProt
- Q05682
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途径
- Myometrial Relaxation and Contraction
抗原
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