Osteocalcin 抗体 (AA 50-99)
(7 references)Quick Overview for Osteocalcin 抗体 (AA 50-99) (ABIN4886487)
抗原
See all Osteocalcin (BGLAP) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 50-99
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原理
- Anti-Osteocalcin/BGLAP Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Osteocalcin/BGLAP Antibody Picoband® (ABIN4886487). Tested in Flow Cytometry, IHC applications. This antibody reacts with Rat.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E. coli-derived rat Osteocalcin recombinant protein (Position: Y50-V99). Rat Osteocalcin shares 80.9% and 68.9% amino acid (aa) sequence identity with human and mouse Osteocalcin, respectively.
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亚型
- IgG
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anti-Osteocalcin (BGLAP) (AA 14-95) antibody
BGLAP 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 21-100) antibodyBGLAP 适用: 人, 大鼠, 小鼠, 犬 WB, ELISA, ICC, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 52-100) antibodyBGLAP 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2D4 unconjugated
anti-Osteocalcin (BGLAP) (AA 1-100) antibodyBGLAP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 21-80) antibodyBGLAP 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), FACS, IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 52-100) antibodyBGLAP 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 2-32) antibodyBGLAP 适用: 人 IHC, WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 21-99) antibodyBGLAP 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 21-99) antibodyBGLAP 适用: 人 IHC, WB 宿主: 小鼠 Monoclonal J10 unconjugated
anti-Osteocalcin (BGLAP) (AA 11-98) antibodyBGLAP 适用: 大鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Rat1. Cancela L, Hsieh CL, Francke U, Price PA (September 1990). "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene". J. Biol. Chem. 265 (25): 15040-8. 2. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G (August 2007). "Endocrine regulation of energy metabolism by the skeleton". Cell 130 (3): 456-69. 3. Puchacz E, Lian JB, Stein GS, Wozney J, Huebner K, Croce C (May 1989). "Chromosomal localization of the human osteocalcin gene". Endocrinology 124 (5): 2648-50. -
说明
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Antibody can be supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Synergistic effects of fibroblast growth factor-2 and bone morphogenetic protein-2 on bone induction." in: Molecular medicine reports, Vol. 16, Issue 4, pp. 4483-4492, (2018) (PubMed).
: "Demineralized bone matrix used for direct pulp capping in rats." in: PLoS ONE, Vol. 12, Issue 3, pp. e0172693, (2017) (PubMed).
: "Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss." in: PLoS ONE, Vol. 12, Issue 8, pp. e0181133, (2017) (PubMed).
: "Intramuscular injection of bone marrow mononuclear cells contributes to bone repair following midpalatal expansion in rats." in: Molecular medicine reports, Vol. 13, Issue 1, pp. 681-8, (2016) (PubMed).
: "Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo." in: Stem cells international, Vol. 2015, pp. 758706, (2015) (PubMed).
: "The osteogenic potential of mesoporous bioglasses/silk and non-mesoporous bioglasses/silk scaffolds in ovariectomized rats: in vitro and in vivo evaluation." in: PLoS ONE, Vol. 8, Issue 11, pp. e81014, (2014) (PubMed).
: "Electrospun poly(L-lactide)/poly(?-caprolactone) blend nanofibrous scaffold: characterization and biocompatibility with human adipose-derived stem cells." in: PLoS ONE, Vol. 8, Issue 8, pp. e71265, (2013) (PubMed).
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: "Synergistic effects of fibroblast growth factor-2 and bone morphogenetic protein-2 on bone induction." in: Molecular medicine reports, Vol. 16, Issue 4, pp. 4483-4492, (2018) (PubMed).
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- Osteocalcin (BGLAP)
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别名
- Bglap
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背景
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Synonyms: Osteocalcin,Bone Gla protein,BGP,Gamma-carboxyglutamic acid-containing protein,Bglap,Bglap2,
Tissue Specificity: Bone.
Background: Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a noncollagenous protein found in bone and dentin. In humans, the osteocalcin is encoded by the BGLAP gene. Its receptor is GPRC6A. It is mapped to 1q22. Osteocalcin may play a role in the body's metabolic regulation and is pro-osteoblastic, or bone-building. It acts as a hormone in the body, causing beta cellsin the pancreas to release more insulin, and at the same time ing fat cells to release the hormone adiponectin, which increases sensitivity to insulin. Also, it may play a role in male fertility. And it is found that picomolar amounts of osteocalcin affected insulin secretion and beta-cell proliferation.
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分子量
- 29 kDa, 60 kDa
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基因ID
- 25295
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UniProt
- P04640
抗原
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