ADC 抗体 (AA 111-301)
Quick Overview for ADC 抗体 (AA 111-301) (ABIN4886479)
抗原
See all ADC 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 111-301
-
原理
- Anti-L-Arginine decarboxylase/AZIN2 Antibody Picoband®
-
交叉反应 （详细）
- No cross-reactivity with other proteins
-
产品特性
- Anti-L-Arginine decarboxylase/AZIN2 Antibody (ABIN4886479). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E. coli-derived human AZIN2 recombinant protein (Position: C111-Q301). Human AZIN2 shares 89.4% amino acid (aa) sequence identity with mouse AZIN2.
-
亚型
- IgG
-
-
anti-Arginine Decarboxylase (ADC) (AA 51-150) antibody
ADC 适用: 人, 小鼠, 大鼠 WB, IF (cc), IF (p), IHC (p), ELISA, IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Arginine Decarboxylase (ADC) (AA 179-228) antibodyADC 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, Pig, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Arginine Decarboxylase (ADC) (AA 1-360) antibodyADC 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Arginine Decarboxylase (ADC) (Middle Region) antibodyADC 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 兔, Cow, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
1. Pitkänen LT, Heiskala M, Andersson LC (2001). "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes".Biochem. Biophys. Res. Commun. 287 (5): 1051-7. 2. Zhu MY, Iyo A, Piletz JE, Regunathan S (2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine". Biochim. Biophys. Acta1670 (2): 156-64. -
说明
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
-
-
- ADC (Arginine Decarboxylase (ADC))
-
别名
- AZIN2
-
背景
-
Synonyms: Antizyme inhibitor 2,AzI2,Arginine decarboxylase,ADC,ARGDC,Ornithine decarboxylase-like protein,ODC-like protein,ornithine decarboxylase paralog,ODC-p,AZIN2,ADC, KIAA1945, ODCP,
Tissue Specificity: Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter. Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis. .
Background: Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is an enzyme that in humans is encoded by the AZIN2 gene. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine, however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion.
-
分子量
- 39 kDa
-
基因ID
- 113451
-
UniProt
- Q96A70
抗原
-
