PLA2R1 抗体 (Internal Region)
Our Local Distributor
北京 101111
Quick Overview for PLA2R1 抗体 (Internal Region) (ABIN487965)
抗原
See all PLA2R1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Internal Region
-
序列
- c-EKKKDTPKQH GT
-
特异性
- This antibody is expected to recognize all reported isoforms (NP_031392.3, NP_001007268.1, NP_001182570.1) of PLA2R1.
-
交叉反应 （详细）
-
Species reactivity (expected):Canine (Dog), Pig.
Species reactivity (tested):Human. -
纯化方法
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
-
免疫原
- Peptide with sequence from the Internal region of the protein sequence according to NP_031392.3, NP_001007268.1.
-
-
anti-phospholipase A2 Receptor 1, 180kDa (PLA2R1) (AA 1418-1487) antibody
PLA2R1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-phospholipase A2 Receptor 1, 180kDa (PLA2R1) (AA 385-643) antibodyPLA2R1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-phospholipase A2 Receptor 1, 180kDa (PLA2R1) (Internal Region) antibodyVerified PLA2R1 适用: 人 ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-phospholipase A2 Receptor 1, 180kDa (PLA2R1) (AA 385-643) antibodyPLA2R1 适用: 人 WB, IHC, ICC, IP 宿主: 小鼠 Monoclonal C6 unconjugated
anti-phospholipase A2 Receptor 1, 180kDa (PLA2R1) (AA 395-530) antibodyPLA2R1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-phospholipase A2 Receptor 1, 180kDa (PLA2R1) (AA 870-1130) antibodyPLA2R1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-phospholipase A2 Receptor 1, 180kDa (PLA2R1) (C-Term) antibodyPLA2R1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Peptide ELISA: 1/64000. Western blot: Approx 140 kDa band observed in Human Ileum lysates (calculated MW of150 kDa according to NP_001007268.1). Recommended concentration: 1 - 3 μg/mL.
-
限制
- 仅限研究用
-
-
-
浓度
- 0.5 mg/mL
-
缓冲液
- Tris buffered saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
-
-
- PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))
-
别名
- PLA2R1 / PLA2R
-
背景
- PLA2R is a receptor for secretory phospholipase A2 (sPLA2). It acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. It is also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, and selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. PLA2R may be involved in responses in proinflammatory cytokine productions during endotoxic shock. It also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.Synonyms: 180 kDa secretory phospholipase A2 receptor, C-type lectin domain family 13 member C, CLEC13C, M-type receptor, PLA2-R, Secretory phospholipase A2 receptor
-
基因ID
- 22925
-
NCBI登录号
- NP_001007268
-
UniProt
- Q13018
-
途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
-
