Methotrexate 抗体
This anti-Methotrexate antibody is a 绵羊 多克隆 antibody detecting Methotrexate in EIA. Suitable for .
Quick Overview for Methotrexate 抗体 (ABIN487772)
抗原
See all Methotrexate (MTX) 抗体
Methotrexate (MTX)
适用
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宿主
绵羊
克隆类型
多克隆
标记
This Methotrexate antibody is un-conjugated
应用范围
Enzyme Immunoassay (EIA)
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纯化方法
- Ig Fraction
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免疫原
- Methotrexate -BSA
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亚型
- IgG
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应用备注
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ELISA: 2.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 7.74 mg/mL (U.V.abs at 280nm)
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缓冲液
- 20 mM Phosphate, 150 mM Sodium Chloride, pH 7.2 containing 0.09 % Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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- Methotrexate (MTX)
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别名
- Methotrexate
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物质类
- Amino Acid
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背景
- Methotrexate (rINN) abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug used in treatment of cancer, autoimmune diseases and as an abortifacient in the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis. The affinity of methotrexate for DHFR is about one thousand-fold that of folate for DHFR. Methotrexate acts specifically during DNA and RNA synthesis, and thus it is cytotoxic during the S-phase of the cell cycle. Logically, it therefore has a greater toxic effect on rapidly dividing cells which replicate their DNA more frequently, and thus inhibits the growth and proliferation of these non-cancerous cells. Lower doses of methotrexate have been shown to be very effective for the management of rheumatoid arthritis, Crohn's disease, and psoriasis.Synonyms: 4-amino-10-methylpteroyl-L-glutamic acid
抗原
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