AGPAT2 抗体
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北京 101111
Quick Overview for AGPAT2 抗体 (ABIN4620346)
抗原
See all AGPAT2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects Lysophosphatidic Acid Acetyltransferase beta.
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纯化方法
- Purified
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免疫原
- Synthetic peptide derived from the LPAAT-beta protein.
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亚型
- IgG
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应用备注
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Western Blot: 5-10 μg/mL. Enzyme Immunoassay. Positive Control: Human Brain Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- Phosphate buffered saline with 0.08 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Ship on dry ice. Store (in aliquots) at -20 °C only.
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- AGPAT2 (1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2))
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别名
- AGPAT2
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背景
- Lysophospholipid Acyltransferases (LPLATs) catalyse the addition of fatty acyl moieties to the glycerol backbone of lysophospholipids . In addition to playing a crutial role in the synthesis of structural membrane components the LPLATs are also implicated in cellular signalling responses for cytokines, growth factors and other agonists. Cellular signalling through the interleukin 1 receptor in human mesangial cells and EL-4 cells proceeds by the activation of lysophosphatidic acid acyltransferase (LPAAT). Activation of LPAAT by interleukin 1 results in the generation of unsaturated phosphatidic acid species, that are crucial to the generation of diacylglycerol and interleukin 1 signalling. LPLATs are also involved in signalling for increased interleukin 2 synthesis through the T cell antigen receptor. Activation of T-cells via anti-CD3 stimulation has been shown to increase incorporation of polyunsaturated fatty acids into phosphatidylcholine via lysophosphatidylcholine acyltransferase. Activation of this enzyme is essential for the sustained activation and translocation of protein kinase C.Synonyms: 1-AGP acyltransferase 2, 1-acyl-sn-glycerol-3-phosphate acyltransferase beta, 1-acylglycerol-3-phosphate O-acyltransferase 2, LPAAT-beta, Lysophosphatidic acid acyltransferase beta
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基因ID
- 10555
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NCBI登录号
- NP_001012745
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UniProt
- O15120
抗原
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