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SPHK1 抗体 (C-Term)

Name: SPHK1 抗体 (C-Term)
SKU: ABIN4620336
Availability: OutOfStock

This anti-SPHK1 antibody is a 兔多克隆 antibody detecting SPHK1 in WB 和 EIA. Suitable for 人, 小鼠, 大鼠和 Cow. This Primary Antibody has been cited in 8+ publications.

(8 references)

产品编号 ABIN4620336

发货至: 中国

Quick Overview for SPHK1 抗体 (C-Term) (ABIN4620336)

抗原

See all SPHK1 抗体

SPHK1 (Sphingosine Kinase 1 (SPHK1))

适用

人, 小鼠, 大鼠, Cow

宿主

兔

克隆类型

多克隆

标记

This SPHK1 antibody is un-conjugated

应用范围

Western Blotting (WB), Enzyme Immunoassay (EIA)

Discover our top product SPHK1 Primary Antibody

抗原表位
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1
C-Term

特异性

This antibody reacts to SPHK1.

纯化方法

Affinity Purified

免疫原

Synthetic peptide derived from the C-terminal of Sphingosine Kinase 1

亚型

IgG
anti-Sphingosine Kinase 1 (SPHK1) (AA 1-384) antibody
SPHK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D6 unconjugated

anti-Sphingosine Kinase 1 (SPHK1) (AA 286-315) antibody
SPHK1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB03621 unconjugated

anti-Sphingosine Kinase 1 (SPHK1) (AA 313-343) antibody
SPHK1 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated

anti-Sphingosine Kinase 1 (SPHK1) (AA 286-315) antibody
SPHK1 适用: 人, 小鼠, 大鼠, 灵长类 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Sphingosine Kinase 1 (SPHK1) (AA 148-398) antibody
SPHK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Sphingosine Kinase 1 (SPHK1) (AA 1-384) antibody
SPHK1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Sphingosine Kinase 1 (SPHK1) (AA 50-384) antibody
SPHK1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Sphingosine Kinase 1 (SPHK1) (AA 1-30), (N-Term) antibody
SPHK1 适用: 人 WB 宿主: 兔 Polyclonal RB3619 unconjugated

anti-Sphingosine Kinase 1 (SPHK1) (AA 59-89) antibody
SPHK1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Sphingosine Kinase 1 (SPHK1) (AA 1-30) antibody
SPHK1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

Western Blot: 1: 400. ELISA. POSITIVE CONTROL: Madin-Darby Bovine Kidney (MDBK) cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
缓冲液

Phosphate buffered saline with 0.08 % sodium azide

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

-20 °C

储存方法

The antibody can be shipped on dry ice. Store (in aliquots) at -20 °C only.
Moles, Urbán, Jiménez-Díaz, Viera-Morilla, Angulo-Barturen, Busquets, Fernàndez-Busquets: "Immunoliposome-mediated drug delivery to Plasmodium-infected and non-infected red blood cells as a dual therapeutic/prophylactic antimalarial strategy." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 210, pp. 217-29, (2016) (PubMed).

Van Vaerenbergh, De Smet, Rafei-Shamsabadi, Blank, Spillner, Ebo, Devreese, Jakob, de Graaf: "IgE recognition of chimeric isoforms of the honeybee (Apis mellifera) venom allergen Api m 10 evaluated by protein array technology." in: Molecular immunology, Vol. 63, Issue 2, pp. 449-55, (2015) (PubMed).

You, Sandalcioglu, Dammann, Felbor, Sure, Zhu: "Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations." in: Journal of cellular and molecular medicine, Vol. 17, Issue 3, pp. 407-18, (2013) (PubMed).

DAngelo, Polishchuk, Di Tullio, Santoro, Di Campli, Godi, West, Bielawski, Chuang, van der Spoel, Platt, Hannun, Polishchuk, Mattjus, De Matteis: "Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide." in: Nature, Vol. 449, Issue 7158, pp. 62-7, (2007) (PubMed).

Kelly, Allport, Yu, Sinh, Sage, Gerszten, Weissleder: "SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration." in: Journal of leukocyte biology, Vol. 81, Issue 3, pp. 748-56, (2007) (PubMed).

Yang, Castle, Hanidu, Stevens, Yu, Li, Stearns, Papov, Rajotte, Li: "Sphingosine kinase 1 is a negative regulator of CD4+ Th1 cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 10, pp. 6580-8, (2005) (PubMed).

Zhao, Usatyuk, Cummings, Saatian, He, Watkins, Morris, Spannhake, Brindley, Natarajan: "Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells." in: The Biochemical journal, Vol. 385, Issue Pt 2, pp. 493-502, (2005) (PubMed).

Katsuma, Hada, Ueda, Shiojima, Hirasawa, Tanoue, Takagaki, Ohgi, Yano, Tsujimoto: "Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 7, Issue 12, pp. 1217-30, (2003) (PubMed).
抗原

SPHK1 (Sphingosine Kinase 1 (SPHK1))

背景

Sphingosine Kinase 1 (Sphk1) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors). These receptors couple to multiple G proteins (e.g.S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide range of cellular events including cell motility, survival, apoptosis, migration and cell-cell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).Synonyms: SPHK, SPK, SPK 1, SPK-1

基因ID

8877

NCBI登录号

NP_001136073

UniProt

Q9NYA1

途径

VEGF Signaling