beta Amyloid 抗体
Our Local Distributor
北京 101111
Quick Overview for beta Amyloid 抗体 (ABIN459388)
抗原
See all beta Amyloid (Abeta) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- Anti-Amyloid beta oligomer-specific monoclonal antibody (OMAB)
-
交叉反应 （详细）
-
Human Abeta oligomers only
Not reactive in: No confirmed exceptions from predicted reactivity are currently known -
预测反应
- Rat
-
纯化方法
- Affinity purified
-
免疫原
- Partly aggregated
-
亚型
- IgM
-
-
anti-Amyloid beta (Abeta) (C-Term) antibody
Abeta 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 小鼠 Monoclonal 9E8-1A3 unconjugated
anti-Amyloid beta (Abeta) (AA 711-760) antibodyAbeta 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (Abeta) antibodyAbeta 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (Abeta) (Ser15) antibodyAbeta 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (Abeta) antibodyAbeta 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (Abeta) antibodyAbeta 适用: 人 WB, ELISA, IHC, IP, IEM 宿主: 兔 Chimeric 6E10 unconjugated Recombinant Antibody
anti-Amyloid beta (Abeta) (pThr743) antibodyAbeta 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Coating antibody at 2 μg/mL (ELISA), 1: 1000 (IF), 1 : 500 (IHC)
-
说明
-
OMAB antibody is a versatile tool within research of Alzheimer's disease. A sandwhich ELISA illustrates its potential regarding its high selectivity towards Aβ oligomers.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- For reconstitution add 100 μL of sterile water
-
缓冲液
- Affinity purified in PBS pH 7.4.
-
注意事项
- Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube
-
储存条件
- 4 °C
-
储存方法
- Store lyophilized/reconstituted at 4°C. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
-
-
- beta Amyloid (Abeta) (Amyloid beta (Abeta))
-
别名
- Amyloid beta oligomer-specific
-
背景
-
Background: Soluble oligomeric assemblies of the Amyloid-β peptide are today anticipated to be the direct cause regarding the Alzheimer pathology. As a consequence, oligomeric Aβ-assemblies constitute a very interesting therapeutic target. Identification of Aβ-oligomers is however, technically challenging due to there labile nature and low abundance. Abeta oligomer-specific OMAB antibody is based on the IgM isotype and represents a new concept of Aβ-oligomer binders using a combination of high avidity and very low monovalent affinity. This combination creates a selectivity of the antibody towards the oligomeric fraction and minimizes reactivity towards monomeric species.
Additional information: OMAB antibody has been purified by by ion-exchange chromatography and is supplied in PBS without any additives as carrier proteins or sodium azide.Binding of OMAB antibody and Abeta oligomers at RT takes about 15 min.Fibrils are inaccessible for OMAB antibodies therefore if a discrimination between fibrils and oligomers is to be achieved, dot blot can be used. Start with antigen concentration of 500 ng/dot followed by 2X dilution steps. Blocking: non-fat milk and washes with 0.3 % Tween 20 in TBS pH 7.4.
-
分子量
- 4.5 kDa
-
途径
- Inflammasome
抗原
-
