SERPINC1 抗体
Quick Overview for SERPINC1 抗体 (ABIN457962)
抗原
See all SERPINC1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- The antiserum does not cross react with any other component of human plasma. Inter-species cross-reactivity is a normal feature of antibodies to plasma proteins since they frequently share antigenic determinants. of this antiserum has not been tested in detail, however in double radial immunodiffusion a reaction has been found with Rhesus monkey.
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产品特性
- Precipitating polyclonal goat antiserum to human antithrombin III
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纯化方法
- Adsorption: Immunoaffinity adsorbed using insolubilized antigens as required, to eliminate antibodies reacting with other plasma proteins. The use of insolubilized adsorption antigens prevents the presence of excess adsorbent protein or immune complexes in the antiserum.
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免疫原
- Antithrombin II is a single polypeptide chain glycoprotein (MW 61,000) with a high degree of homology with the alpha-1 antitrypsin. It is a circulating natural anticoagulant acting as a proteinase inhibitor. It is synthesized in the liver and the vascular endothelial cells. In electrophoresis of plasma it migrates in the alpha-1 region and is consumed during coagulation in vivo. Antithrombin III inhibits the action of factors IXa, Xa, XIIa, thombin and kallikrein by forming a stable complex. Heparin acts as a cofactor which greatly increases its inhibitory activities. Normal adult plasma contain an average of 0.15 mg antithrombin III per ml. This can vary from 75 to 128%. A partial deficiency in antithrombin III activity in the plasma (less than 50%) will result in an increased tendency to recurrent thrombo-enbolism. Several types of congenital deficiency have been reported. Most common type 1 deficiency patients have reduced antithrombin III antigen and activity levels. Heterozygotes have levels of 25 to 50% of normal values. For use as an immunogen antithrombin III is isolated and highly purified from pooled plasma. Freund’s complete adjuvant is used in the first step of the immunization procedure.
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亚型
- IgG
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anti-Serpin Family C Member 1 (SERPINC1) antibody
SERPINC1 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C3 unconjugated
anti-Serpin Family C Member 1 (SERPINC1) (AA 150-426) antibodySERPINC1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Serpin Family C Member 1 (SERPINC1) (AA 33-465) antibodySERPINC1 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Serpin Family C Member 1 (SERPINC1) (AA 33-465) antibodySERPINC1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Serpin Family C Member 1 (SERPINC1) (AA 1-259) antibodySERPINC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B12 unconjugated
anti-Serpin Family C Member 1 (SERPINC1) (AA 364-393), (C-Term) antibodySERPINC1 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB18489 unconjugated
anti-Serpin Family C Member 1 (SERPINC1) (AA 37-180) antibodySERPINC1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Serpin Family C Member 1 (SERPINC1) (AA 33-185) antibodySERPINC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Serpin Family C Member 1 (SERPINC1) antibodySERPINC1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Serpin Family C Member 1 (SERPINC1) (AA 141-211) antibodySERPINC1 适用: 人, 小鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- The anodic mobility enables quantitative determination of antithrombin III using the standard EID technique (Laurell). Immunoelectrophoresis and radial immunodiffusion are used to identify antithrombin III and enzyme inhibitor complexes. Double radial immunodiffusion (Mancini) is also used for quantitative assays. If applied in more sensitive test procedures, in Immunohistochemistry, or solid phase immunoassays, appropriate specificity controls should always be included. Plasma samples and all assay components must contain EDTA to stabilize the proteins.
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限制
- 仅限研究用
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状态
- Lyophilized
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浓度
- Total protein and IgG concentrations in the antiserum are comparable to those of pooled normal goat serum. No foreign proteins added. Antibody titre: Precipitin titre 1:32 when tested against in agar-block immunodiffusion titration against normal human pl
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缓冲液
- Delipidated, heat inactivated, lyophilized, stable whole antiserum
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储存液
- Without preservative
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储存条件
- 4 °C
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- SERPINC1 (Serpin Family C Member 1 (SERPINC1))
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别名
- Antithrombin III
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背景
- The reactivity of the antiserum is restricted to antithrombin III. In immunoelectrophoresis and radial immunodiffusion (Ouchterlony), using various antiserum concentrations against fresh normal human plasma a single precipitin line is obtained which shows a reaction of identity with the precipitin line obtained with purified antithrombin III. No reaction is obtained with any other plasma protein including the main proteinase inhibitors known to have structural homology with antithrombin III. Protein complexes containing antithrombin III may also react
抗原
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