VCAM1 抗体
Quick Overview for VCAM1 抗体 (ABIN457435)
抗原
See all VCAM1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Hu CD106 Purified
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特异性
- The mouse monoclonal antibody STA recognizes an extracellular epitope of CD106 antigen (VCAM-1), a 100-110 kDa type I membrane protein of the immunoglobulin superfamily, a crucial mediator of leukocyte adhesion, and a costimulation molecule.
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交叉反应 (详细)
- Human
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Human DS6 T cell line
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亚型
- IgG1
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应用备注
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Flow cytometry: Recommended dilution: 4-6 μg/mL, positive control: TNF-alpha activated HUVEC cells.
Immunohistochemistry (frozen sections): Acetone fixation.
ELISA: Capture mAb for soluble CD106. -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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Modeling the early events of severe acute respiratory syndrome coronavirus infection in vitro." in: Journal of virology, Vol. 80, Issue 6, pp. 2684-93, (2006) (PubMed).
: "
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Modeling the early events of severe acute respiratory syndrome coronavirus infection in vitro." in: Journal of virology, Vol. 80, Issue 6, pp. 2684-93, (2006) (PubMed).
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- VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))
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别名
- CD106
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背景
- Vascular cell adhesion molecule 1,CD106 / VCAM-1 (vascular cell adhesion molecule-1) is an Ig-like cell surface adhesion molecule binding VLA-4 integrin. VCAM-1 is a potent T cell costimulatory molecule taking part in their positive selection and survival, as well as in adhesion, transendothelial migration and activation of peripheral T cells. VCAM-1 is also involved in endothelial cell-cell contacts. Whereas VCAM-1 normally mediates leukocyte extravasion to sites of tissue inflammation, tumour cells can use overexpressed VCAM-1 to escape T cell immunity. Soluble form of VCAM-1 (sVCAM-1) is an inflammatory marker and can be used also in prognosis of subsequent cariovascular events following acute coronary syndromes.,VCAM-1, INCAM-100
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基因ID
- 7412
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UniProt
- P19320
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途径
- Carbohydrate Homeostasis
抗原
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