CRYAA 抗体
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Quick Overview for CRYAA 抗体 (ABIN453938)
抗原
See all CRYAA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody recognizes Alpha A Crystallin at ~20 kDa. Detects alpha Crystallin complex (containing Alpha A and Alpha B subunits). Does not cross react with Alpha B Crystallin, Beta-L Crystallin, Beta-H Crystallin, Gamma Crystallin, Hsp25, Hsp27 or Hsp47 proteins.
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse, Cow, Rat.
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产品特性
- Synonyms: CRYAA, CRYA1, HSPB4, Heat shock protein beta-4
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纯化方法
- Protein G affinity chroamtography
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免疫原
- Native alpha crystallin
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亚型
- IgG1
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anti-Crystallin, alpha A (CRYAA) antibody
CRYAA 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2C3 unconjugated
anti-Crystallin, alpha A (CRYAA) (AA 1-173) antibodyCRYAA 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Crystallin, alpha A (CRYAA) antibodyCRYAA 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Crystallin, alpha A (CRYAA) (AA 1-173) antibodyCRYAA 适用: 人, 小鼠, 大鼠 WB, ICC, IHC, FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Crystallin, alpha A (CRYAA) (AA 77-106) antibodyCRYAA 适用: 人 WB 宿主: 兔 Polyclonal RB28544 unconjugated
anti-Crystallin, alpha A (CRYAA) antibody (Atto 390)CRYAA 适用: 人 WB, ELISA, IF, ICC 宿主: 小鼠 Monoclonal 1H3-B8 Atto 390
anti-Crystallin, alpha A (CRYAA) antibody (Biotin)CRYAA 适用: 人 WB, ELISA, IF, ICC 宿主: 小鼠 Monoclonal 1H3-B8 Biotin
anti-Crystallin, alpha A (CRYAA) antibody (FITC)CRYAA 适用: 人 WB, ELISA, IF, ICC 宿主: 小鼠 Monoclonal 1H3-B8 FITC
anti-Crystallin, alpha A (CRYAA) antibody (HRP)CRYAA 适用: 人 WB, ELISA, IF, ICC 宿主: 小鼠 Monoclonal 1H3-B8 HRP
anti-Crystallin, alpha A (CRYAA) antibody (Atto 488)CRYAA 适用: 人 WB, ELISA, IF, ICC 宿主: 小鼠 Monoclonal 1H3-B8 Atto 488
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应用备注
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Western blot: 1/2000. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS pH 7.2, 0.09 % Sodium Azide, 50 % Glycerol
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
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Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing andthawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- CRYAA (Crystallin, alpha A (CRYAA))
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别名
- alpha-Crystallin A Chain
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背景
- The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alphacrystallins possess structural and functional similarities with Hsp25 and Hsp27 (1). Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance (2). In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases (8).Synonyms: CRYA1, CRYAA, HSPB4, Heat shock protein beta-4
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基因ID
- 1409
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UniProt
- P02489
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途径
- M Phase
抗原
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