ASPSCR1 抗体 (C-Term)
Quick Overview for ASPSCR1 抗体 (C-Term) (ABIN453522)
抗原
See all ASPSCR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody is specific to ASPSCR1/TUG (C-term).
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Protein A Chromatography followed by peptide affinity purification.
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免疫原
- KLH conjugated synthetic peptide selected from the C-terminal region of Human ASPSCR1.
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anti-Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) (AA 284-553) antibody
ASPSCR1 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) (AA 1-553) antibodyASPSCR1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D10-1D11 unconjugated
anti-Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) (AA 284-553) antibodyASPSCR1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) (AA 1-553) antibodyASPSCR1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) (AA 392-418) antibodyASPSCR1 适用: 人 WB, IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) antibodyASPSCR1 适用: 小鼠 WB, ELISA 宿主: 小鼠 Monoclonal 4A11A6G11 unconjugated
anti-Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) (AA 392-418), (C-Term) antibodyASPSCR1 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB23529 unconjugated
anti-Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) antibodyASPSCR1 适用: 人, 小鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) antibodyASPSCR1 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) (AA 258-307) antibodyASPSCR1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA: 1/1,000. Western blot: 1/100approx. 1/500.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS containing 0.09 % (W/V) Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- ASPSCR1 (Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1))
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别名
- ASPSCR1
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背景
- ASPSCR1 is tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Insulin stimulates glucose uptake in fat and muscle by mobilizing the GLUT4 glucose transporter. GLUT4 is sequestered intracellularly in the absence of insulin, and is redistributed to the plasma membrane within minutes of insulin stimulation. Bogan et al. (2003) described a functional screen to identify proteins that modulate GLUT4 distribution, and identified TUG as a putative tether, containing a UBX domain, for GLUT4. They identified the ASPL protein as the probable human homolog of murine TUG. In truncated form, TUG acts in a dominant-negative manner to inhibit insulin-stimulated GLUT4 redistribution in Chinese hamster ovary cells and 3T3-L1 adipocytes. Full-length TUG forms a complex specifically with GLUT4, in 3T3-L1 adipocytes, this complex is present in unstimulated cells and is largely disassembled by insulin. Endogenous TUG is localized with the insulin-mobilizable pool of GLUT4 in unstimulated 3T3-L1 adipocytes, and is not mobilized to the plasma membrane by insulin. Distinct regions of TUG are required to bind GLUT4 and to retain GLUT4 intracellularly in transfected, nonadipose cells. Bogan et al. (2003) concluded that TUG traps endocytosed GLUT4 and tethers it intracellularly, and that insulin mobilizes this pool of retained GLUT4 by releasing this tether. Bogan et al. (2003) found that TUG exists in 2 isoforms, the longer of which contains a sequence at the amino terminus with similarity to ubiquitin that is predicted to be 550 residues long. The probable start codon in the short form is equivalent to methionine-78 of the long form.Synonyms: ASPL, Alveolar soft part sarcoma chromosomal region candidate gene 1 protein, Alveolar soft part sarcoma locus, RCC17, Renal papillary cell carcinoma protein 17, TUG, Tether containing UBX domain for GLUT4, UBX domain-containing protein 9, UBXD9, UBXN9
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基因ID
- 79058
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NCBI登录号
- NP_076988
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UniProt
- Q9BZE9
抗原
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