FOXE1 抗体 (C-Term)
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Quick Overview for FOXE1 抗体 (C-Term) (ABIN452689)
抗原
See all FOXE1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- Recognizes FOXE1 / TTF2 at C-term.
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交叉反应 （详细）
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Species reactivity (expected):Bat, Elephant, Marmoset, Gorilla, Monkey, Rabbit.
Species reactivity (tested):Human. -
纯化方法
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
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免疫原
- Peptide with sequence C-AYPGGIDRFVSAM, from the C Terminus of the protein sequence according to NP_004464.2. Genename: FOXE1
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anti-Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) (AA 101-200) antibody
FOXE1 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) (C-Term) antibodyVerified FOXE1 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) (N-Term) antibodyFOXE1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) (AA 184-365) antibodyFOXE1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) (C-Term) antibodyFOXE1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) (N-Term) antibodyFOXE1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) (N-Term) antibodyFOXE1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) (AA 10-59) antibodyFOXE1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) (AA 51-100) antibodyFOXE1 适用: 人, 小鼠, 大鼠 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) (AA 254-303) antibodyFOXE1 适用: 人, 小鼠, 大鼠, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Peptide ELISA: Limit Dilution: 1/32000. Western blot: Preliminary experiments gave an approx 70 kDa band in Human Thymus andThyroid Gland lysates after 0.3 μg/mL antibody staining. Please note that currently wecannot find an explanation in the literature for the band we observe given the calculated
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- FOXE1 (Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1))
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别名
- FOXE1 / FKHL15
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背景
- Forkhead box protein E1 (FOXE1) is a member of the forkhead/ winged-helix domain transcription factor family. FOXE1, also designated FKHL15 or TTF-2, complexes with TTF-1 and Pax-8 to induce thyroid follicular cell differentiation and thyroid hormone biosynthesis by regulating the expression of the sodium iodide symporter (NIS), thyroid peroxidase (TPO), thyroglobulin (TG) and the thyrotropin receptor (TSHR). FOXE1 encodes a protein that is expressed in several tissues, including thymus, adult brain, lung, liver, heart and pancreas. The chromosomal location of the FOXE1 gene on 9q22 suggests that it may be involved in squamous cell epithelioma and hereditary sensory neuropathy type I. Mutations in the FOXE1 gene lead to the development of congenital hypothyroidism, which occurs in approximately one in four thousand newborns and results in complete or partial failure of thyroid gland development. Patients who are homozygous for a missense mutation in the forkhead domain of he FOXE1 gene can also develop thyroid agenesis, cleft palate and choanal atresia. Subsequently, the FOXE1 gene may used as a marker to study these disorders.Synonyms: FOXE2, Forkhead box protein E1, HFKH4, HFKL5, HNF-3/fork head-like protein 5, TITF2, TTF-2, TTF2, Thyroid transcription factor 2
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基因ID
- 2304
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NCBI登录号
- NP_004464
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UniProt
- O00358
抗原
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