HCV Core Protein 抗体
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北京 101111
Quick Overview for HCV Core Protein 抗体 (ABIN452510)
抗原
See all HCV Core Protein (HCV C) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应 （详细）
- Species reactivity (tested):Human.
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产品特性
- Synonyms: Hepatitis C Virus
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纯化方法
- Affinity chromatography on Protein G.
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免疫原
- Synthetic peptides derived from HCV Capsid Protein
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亚型
- IgG1
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anti-Hepatitis C Virus Core Protein (HCV C) (AA 13-124), (AA 369-704) antibody (Biotin)
HCV C 适用: Hepatitis C Virus (HCV) WB, ELISA, IF, IHC 宿主: 小鼠 Monoclonal H6-29 Biotin
anti-Hepatitis C Virus Core Protein (HCV C) (AA 13-124), (AA 369-704) antibody (FITC)HCV C 适用: Hepatitis C Virus (HCV) IF, IHC 宿主: 小鼠 Monoclonal H6-29 FITC
anti-Hepatitis C Virus Core Protein (HCV C) antibodyHCV C 适用: Hepatitis C Virus (HCV) WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA: HCV Core Protein antibody (clone A1/3D1) was tested using indirect ELISA method. The testing plates were coated with HCV non-structural protein (NS), Capsid Protein (C) andthe mixture of NS and C separately. The neat culture supernatant of hybridoma showed a strong reaction with HCV capsidprotein (OD492 value > 2.0) and mixture of NS and C (OD492 value >1.5), and have noreaction with HCV Non-structural protein (OD492 value < 0.03). Not suitable for use in Western Blots. Has been used successfully in the recognition of in-vitro translated HCV core protein.
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限制
- 仅限研究用
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溶解方式
- Restore with Double distillated water to adjust the final concentration to 1.0 mg/mL
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缓冲液
- 0.01 M PBS, pH 7.0 without preservatives.
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
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Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))
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别名
- HCV Core Protein
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物质类
- Viral Protein
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背景
- The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein, it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.Synonyms: Hepatitis C Virus core protein
抗原
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