Peptide ELISA: 1/32000. Immunofluorescence. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
UNC5C is a receptor for netrin required for axon guidance. It mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It is also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. There are two named isoforms.Synonyms: Netrin receptor UNC5C, Protein unc-5 homolog C, UNC5H3, Unc-5 homolog 3