TNKS 抗体 (N-Term)
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北京 101111
Quick Overview for TNKS 抗体 (N-Term) (ABIN401535)
抗原
See all TNKS 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody detects Tankyrase-1 (TANK1) at N-term. No cross reactivity expected to TANK2.
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交叉反应 （详细）
- Species reactivity (tested):Human
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纯化方法
- Ammonium sulphate precipitation followed by affinity chromatography using Protein G
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免疫原
- Fusion protein containing 120aa amino acids from N Terminal region of the protein sequence according to NP_003738.2 . Genename: TNKS
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anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) (AA 1017-1124) antibody
TNKS 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1A2 unconjugated
anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) (AA 35-130) antibodyTNKS 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) (Middle Region) antibodyTNKS 适用: 人, 小鼠, 大鼠, Cow, 兔, 马, 犬, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) (AA 1017-1124) antibodyTNKS 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A3 unconjugated
anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) (AA 972-1021) antibodyTNKS 适用: 人, Cow, 兔, Pig, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) (N-Term) antibodyVerified TNKS 适用: 人 WB 宿主: 山羊 Polyclonal unconjugated
anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) (AA 1277-1327) antibodyTNKS 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) (AA 1079-1128) antibodyTNKS 适用: 人, 小鼠, 大鼠, Cow, 兔, 马, 犬, 豚鼠, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) (AA 448-497) antibodyTNKS 适用: 人, 小鼠, 大鼠, Cow, 兔, 马, 犬, 豚鼠, Pig, 斑马鱼, Bat, 猴, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) (Middle Region) antibodyTNKS 适用: 人, 小鼠, 大鼠, Cow, 兔, 马, 犬, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western blot: In transfected HEK293 transiently expressing TANK1 a band of approx.142 kDa is observed. This band is not observed in the non-transfected HEK293. Thecalculated molecular size is 142 kDa according to NP_003738.2. Recommendedconcentration, 0.5-1.5 μg/mL. Full caption )see picture below): HEK293 overexpressing TANK1 (lane 2) and TANK2 (lane 4)and probed with EB02508 (mock transfection in first lane). Lane three is empty. Lower
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
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- TNKS (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS))
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别名
- Tankyrase-1 (TANK1)
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背景
- Tankyrase is a protein with homology to ankyrins as well as to the catalytic domain of poly (adenosine diphosphate ribose) polymerase (PARP). Tankyrase localizes to telomeres by binding to the telomeric repeat binding factor 1 (TRF1) through its ankyrin repeats. TRF1 is a negative regulator of telomere length maintenance. Tankyrase exhibits PARP activity functioning as acceptors for adenosine diphosphate (ADP) ribosylation. Since ADP ribosylation of TRF1 diminishes its ability to bind to telomeric DNA, this suggests that telomere function in human cells is regulated by poly (ADP) ribosylation. Both the cell cycle and TRF1 may regulate the subcellular localization of tankyrase. During interphase tankyrase colocalizes with TRF1 to telomeres plus nuclear pore complexes whereas during mitosis tankyrase localizes around the pericentriolar matrix of mitotic chromosomes. Tankyrase may regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4 vesicles.Synonyms: PARP5A, PARPL, TIN1, TINF1, TNKS, TNKS-1, TNKS1, TRF1-interacting ankyrin-related ADP-ribose polymerase, Tankyrase I
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基因ID
- 8658
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NCBI登录号
- NP_003738
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UniProt
- O95271
抗原
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