HMOX2 抗体 (Internal Region)
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Quick Overview for HMOX2 抗体 (Internal Region) (ABIN401519)
抗原
See all HMOX2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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序列
- c-DQAGSTLARE TLED
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特异性
- This antibody detects HMOX2 (Internal).
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交叉反应 (详细)
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Species reactivity (expected):Mouse, Bovine.
Species reactivity (tested):Human. -
纯化方法
- Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
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免疫原
- Peptide from the internal region of the protein sequence according to NP_002125.3 . Genename: HMOX2
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应用备注
- Peptide ELISA: antibody detection limit dilution 1: 32000. Western blot: Recommended concentration: 0.3-1 μg/mL. Approx 37 kDa band observed inlysates of cell line K562 (calculated MW of 36.7 kDa according to NP_002125.3).
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
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- HMOX2 (Heme Oxygenase (Decycling) 2 (HMOX2))
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别名
- Heme Oxygenase 2 (HMOX2)
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背景
- Heme oxygenase (HO) is a microsomal enzyme involved in cellular response to oxidative stress. HO oxidatively cleaves the heme ring at the alpha methene bridge to form carbon monoxide and biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Two heme oxygenase isozymes, termed HO 1 and HO 2, have been identified so far. At the amino acid level, HO 1 and HO 2 are 42 % homologous. However, each isozyme is evolutionary highly conserved. HO 1 is the inducible form of the enzyme and is therefore also referred to as stress protein Hsp32. Expression of HO 1 can be induced by a variety of stimuli such as heme, metals, hormones, UV radiation and sulfhydryl depleting agents. In contrast, HO 2 is the constituitive form of the enzyme. It is not inducible by exogeneous stimuli and HO 2 is the most prevalent form in most tissues, except the spleen where HO 1 levels are predominant under normal conditions.Synonyms: HO-2, HO2
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基因ID
- 3163
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NCBI登录号
- NP_002125
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UniProt
- P30519
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途径
- Transition Metal Ion Homeostasis
抗原
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