MYB 抗体 (Internal Region)
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北京 101111
Quick Overview for MYB 抗体 (Internal Region) (ABIN401456)
抗原
See all MYB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- This antibody reacts with endogenous c-Myb protein and also SUMOylated overexpressed c-Myb protein in transfected Cos7 cells.
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纯化方法
- Affinity chromatography
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免疫原
- Peptide corresponding to an internal portion of the c-Myb protein
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亚型
- IgG
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应用备注
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ELISA: 1/10,000 - 1/25,000. Western Blot: 1/250 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL (by UV absorbance at 280 nm)
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缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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- MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))
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别名
- MYB
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背景
- The transcription factor c-Myb plays an important role in the development of all hematopoietic lineages during definitive hematopoiesis. Its critical role in hematopoiesis has been first demonstrated in experiments with targeted disruption of the c-Myb gene where deletion of both alleles of the c-Myb gene was embryonally lethal due to severe anemia. c-Myb is a short-lived sequence specific DNA-binding protein that regulates transcription of several important genes involved directly in cellular processes such as proliferation, differentiation, and apoptosis. Posttranslational modifications such as phosphorylation, acetylation, ubiquitination, and conjugation of SUMO proteins are crucial for modulation of the transactivation activity of c-Myb.Synonyms: Proto-oncogene c-Myb, Transcriptional activator Myb, c-Myb
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基因ID
- 17863
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NCBI登录号
- NP_001185843
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UniProt
- P06876
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途径
- Chromatin Binding, Positive Regulation of Immune Effector Process
抗原
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