PTENP1 抗体 (N-Term)
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北京 101111
Quick Overview for PTENP1 抗体 (N-Term) (ABIN401437)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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交叉反应 (详细)
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Species reactivity (expected):Mouse, Rat, Canine, Macaque, Chimpanzee, Opossum, Zebrafish, Green pufferfish, Platypus.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
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免疫原
- Purified peptide corresponding to amino acids near the N-terminal end of human PTEN-P1 protein
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亚型
- IgG
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应用备注
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ELISA: 1/160,000. Western Blot: 1/500 to 1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.73 mg/mL (by UV absorbance at 280 nm)
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缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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- PTENP1 (Phosphatase and Tensin Homolog Pseudogene 1 (PTENP1))
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别名
- PTENP1
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背景
- This gene (PTENP1) is a highly homologous pseudogene of PTEN. PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.Synonyms: PTEN-rs, PTEN2, PTH2, Phosphatase and tensin homolog 2, Phosphatase and tensin homolog pseudogene 1, psiPTEN
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基因ID
- 9606
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UniProt
- O43460
抗原
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