AHSA1 抗体 (Internal Region)
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Quick Overview for AHSA1 抗体 (Internal Region) (ABIN401377)
抗原
See all AHSA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- This antibody is directed against AHA1 protein.
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交叉反应 （详细）
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Species reactivity (expected):Chimpanzee.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
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免疫原
- Synthetic peptide corresponding to an internal region of human AHA1 protein
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亚型
- IgG
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anti-Activator of HSP90 ATPase Activity 1 (AHSA1) (Internal Region) antibody
AHSA1 适用: 人, 猴 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Activator of HSP90 ATPase Activity 1 (AHSA1) antibody (Atto 390)AHSA1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC 宿主: 大鼠 Monoclonal 25F2-D9 Atto 390
anti-Activator of HSP90 ATPase Activity 1 (AHSA1) antibody (Atto 488)AHSA1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC 宿主: 大鼠 Monoclonal 25F2-D9 Atto 488
anti-Activator of HSP90 ATPase Activity 1 (AHSA1) antibody (Biotin)AHSA1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC 宿主: 大鼠 Monoclonal 25F2-D9 Biotin
anti-Activator of HSP90 ATPase Activity 1 (AHSA1) antibody (HRP)AHSA1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC 宿主: 大鼠 Monoclonal 25F2-D9 HRP
anti-Activator of HSP90 ATPase Activity 1 (AHSA1) antibody (FITC)AHSA1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC 宿主: 大鼠 Monoclonal 25F2-D9 FITC
anti-Activator of HSP90 ATPase Activity 1 (AHSA1) antibody (APC)AHSA1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC 宿主: 大鼠 Monoclonal 25F2-D9 APC
anti-Activator of HSP90 ATPase Activity 1 (AHSA1) antibody (Atto 594)AHSA1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC 宿主: 大鼠 Monoclonal 25F2-D9 Atto 594
anti-Activator of HSP90 ATPase Activity 1 (AHSA1) antibody (PerCP)AHSA1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC 宿主: 大鼠 Monoclonal 25F2-D9 PerCP
anti-Activator of HSP90 ATPase Activity 1 (AHSA1) antibody (PE)AHSA1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC 宿主: 大鼠 Monoclonal 25F2-D9 PE
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应用备注
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ELISA: 1/35,000 - 1/185,000. Western Blot: 1/500 - 1/3,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.08 mg/mL (by UV absorbance at 280 nm)
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缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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- AHSA1 (Activator of HSP90 ATPase Activity 1 (AHSA1))
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别名
- AHA1 / AHSA1
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背景
- Activator of Hsp90 ATPase (AHA1) stimulates the inherent ATPase cycle of Hsp90, which is essential for its chaperone activity in vivo. The activation and/or stability of many of the key regulatory and signaling proteins of the eukaryotic cell depend on their interaction with the Hsp90 Molecular chaperone. Hsp90 is assisted and regulated by co-chaperones that participate in an ordered series both to assist clientprotein recruitment or release and to modulate progress through the ATPase coupled chaperone cycle. Structural analysis and mutagenesis show that binding of the N-terminal domain of AHA1 to Hsp90 promotes a conformational switch in the middle-segment catalytic loop (aa 370-390) of Hsp90 that exposes the catalytic Arg380 and enables its interaction with ATP in the N-terminal nucleotide-binding domain of the chaperone. Recent studies show that AHA1 modulates Hsp90-dependent stability of the folding of the cystic fibrosis transmembrane conductance regulator (CFTR) in the endoplasmic reticulum (ER). Down-regulation of AHA1 rescues misfolding of CFTR in cystic fibrosis.Synonyms: Activator of 90 kDa heat shock protein ATPase homolog 1, C14orf3, HSPC322
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基因ID
- 10598
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NCBI登录号
- NP_036243
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UniProt
- O95433
抗原
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