This antibody is directed against Mouse ZIC2 protein. A BLAST analysis was used to suggest reactivity with this protein from Human, Chimpanzee, Mouse, Rat and Dog based on 100 % homology for the immunogen sequence. Expect cross reactivity with ZIC2 from Chicken, Zebrafish and Frog as the core 16 amino acid residues within the immunogen sequence show very high degrees of homology with ZIC2 from these sources. Cross reactivity with ZIC2 homologues from other sources has not been determined.
交叉反应 (详细)
Species reactivity (expected):Human, Chimpanzee, Mouse, Rat, Canine, Chicken, Zebrafish, Frog. Species reactivity (tested):Mouse.
纯化方法
Affinity Chromatography
免疫原
Synthetic peptide corresponding amino acids 189-206 of Mouse ZIC-2
ELISA: 1/10,000 - 1/50,000. Western Blot: 1/500 - 1/2,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
浓度
1.0 mg/mL (by UV absorbance at 280 nm)
缓冲液
0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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背景
ZIC2 (also known as zinc finger protein of the cerebellum 2, HPE5, Zic family member 2 and odd-paired Drosophila homolog) is a nuclear protein that functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. In mouse, knockout of Zic1 leads to aplasia of cerebellum and skeletal abnormalities. Mutation in Zic2 and Zic3 in mouse and/or human cause holoprosencephaly and heterotaxis, respectively. Holoprosencephaly is the most common structural anomaly of the human brain.Synonyms: Zinc finger protein ZIC 2, Zinc finger protein of the cerebellum 2