TP53BP2 抗体
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北京 101111
Quick Overview for TP53BP2 抗体 (ABIN401045)
抗原
See all TP53BP2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody is directed against ASPP2.
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交叉反应 （详细）
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Species reactivity (expected):Canine (100 %), Macaque (100 %), Mouse (80 %), Rat (80 %).
Species reactivity (tested):Human. -
纯化方法
- Affinity Chromatography on Protein A
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免疫原
- Synthetic peptide corresponding to an internal sequence of Human ASPP2 . Genename: ASPP2
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亚型
- IgG
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anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) (AA 511-610) antibody
TP53BP2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) (AA 1001-1128) antibodyTP53BP2 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) antibodyTP53BP2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2145 unconjugated Recombinant Antibody
anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) (AA 511-610) antibodyTP53BP2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) antibodyTP53BP2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) (AA 360-600) antibodyTP53BP2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) (AA 133-182) antibodyTP53BP2 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠, Pig, Bat, 小鸡, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) (N-Term) antibodyTP53BP2 适用: 人, 小鼠, 大鼠, 犬, Cow, 斑马鱼, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/2,500-1/10,000. Western Blot: 1/500-1/3,000. Expect a band approximately 125 kDa in size correspondingto ASPP2 in the appropriate cell lysate or extract.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 2.4 mg/mL (by UV absorbance at 280 nm)
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缓冲液
- 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.
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- TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))
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别名
- TP53BP2
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背景
- ASPP (ankyrinrepeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, iASPP functionally inactivates p53. ASPPs may also regulate p63-and p73-mediated apoptosis. Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3. Not all cell cycle arrest genes are affected, such as p21. Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53. Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.Synonyms: 53BP2, ASPP2, Apoptosis-stimulating of p53 protein 2, BBP, Bcl2-binding protein, NY-REN-51, Tumor suppressor p53-binding protein 2, p53-binding protein 2, p53BP2
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基因ID
- 7159
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NCBI登录号
- NP_001026855
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UniProt
- Q13625
抗原
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