TP53BP2 抗体
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- 抗原 See all TP53BP2 抗体
- TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))
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适用
- 人, 犬, Macaque
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TP53BP2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- 特异性
- This antibody is directed against ASPP2.
- 交叉反应 （详细）
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Species reactivity (expected):Canine (100 %), Macaque (100 %), Mouse (80 %), Rat (80 %).
Species reactivity (tested):Human. - 纯化方法
- Affinity Chromatography on Protein A
- 免疫原
- Synthetic peptide corresponding to an internal sequence of Human ASPP2 . Genename: ASPP2
- 亚型
- IgG
- Top Product
- Discover our top product TP53BP2 Primary Antibody
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anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) (AA 511-610) antibody
TP53BP2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) (AA 1001-1128) antibodyTP53BP2 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) antibodyTP53BP2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) antibodyTP53BP2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) (AA 360-600) antibodyTP53BP2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) (AA 511-610) antibodyTP53BP2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) (AA 133-182) antibodyTP53BP2 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠, Pig, 小鸡, 猴, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) (Internal Region) antibodyTP53BP2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA: 1/2,500-1/10,000. Western Blot: 1/500-1/3,000. Expect a band approximately 125 kDa in size correspondingto ASPP2 in the appropriate cell lysate or extract.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 2.4 mg/mL (by UV absorbance at 280 nm)
- 缓冲液
- 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide as preservative
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.
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- 抗原
- TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))
- 别名
- TP53BP2 (TP53BP2 产品)
- 别名
- 53BP2 antibody, ASPP2 antibody, BBP antibody, P53BP2 antibody, PPP1R13A antibody, TP53BP2 antibody, AI746547 antibody, Tp53bp2 antibody, X98550 antibody, Trp53bp2 antibody, wu:fa09h08 antibody, wu:fb04e08 antibody, zgc:85720 antibody, tumor protein p53 binding protein 2 antibody, tumor protein p53 binding protein 2 L homeolog antibody, tumor protein p53 binding protein, 2b antibody, transformation related protein 53 binding protein 2 antibody, tumor protein p53 binding protein, 2 antibody, tumor protein p53 binding protein, 2a antibody, TP53BP2 antibody, tp53bp2.L antibody, tp53bp2 antibody, tp53bp2b antibody, Trp53bp2 antibody, Tp53bp2 antibody, tp53bp2a antibody
- 背景
- ASPP (ankyrinrepeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, iASPP functionally inactivates p53. ASPPs may also regulate p63-and p73-mediated apoptosis. Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3. Not all cell cycle arrest genes are affected, such as p21. Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53. Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.Synonyms: 53BP2, ASPP2, Apoptosis-stimulating of p53 protein 2, BBP, Bcl2-binding protein, NY-REN-51, Tumor suppressor p53-binding protein 2, p53-binding protein 2, p53BP2
- 基因ID
- 7159
- NCBI登录号
- NP_001026855
- UniProt
- Q13625
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