FOXO1 抗体 (AA 242-655)
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北京 101111
Quick Overview for FOXO1 抗体 (AA 242-655) (ABIN400650)
抗原
See all FOXO1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 242-655
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特异性
- This antibody recognizes Human FKHR.
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交叉反应 (详细)
- Species reactivity (tested):Human.
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产品特性
- Synonyms: Forkhead Box Protein O1, FOXO1, FKHR, Forkhead Box Protein O1A, Forkhead inRhabdomyosarcoma
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纯化方法
- Protein G Chromatography.
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免疫原
- Fusion protein containing the region encoding aa 242-655 of Human FOXO1A expressed inE. coli.
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亚型
- IgG1
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应用备注
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Western Blot: 0.1-2.0 μg/mL. Immunohistochemistry on Paraffin Sections: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH 7.2 containing no preservatives.
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储存液
- Without preservative
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储存条件
- 4 °C/-20 °C
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储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- FOXO1 (Forkhead Box O1 (FOXO1))
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别名
- FOXO1A
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背景
- FOXO1A (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein which is a member of a subfamily of the forkhead homeotic gene family of transcription factors. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined, however, it may play a role in myogenic growth and differentiation. Chromosomal aberrations involving FOXO1A are a cause of rhabdomyosarcoma 2 (RMS2), also known as alveolar rhabdomyosarcoma.Synonyms: FKHR, FOXO1, Forkhead Box Protein O1, Forkhead Box Protein O1A, Forkhead in Rhabdomyosarcoma
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基因ID
- 2308
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UniProt
- Q12778
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途径
- PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling
抗原
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